LondonThe same drugs harm one liver, not another.
Inherited variants change how strongly other drugs block OATP1B1, the liver’s drug transporter.
The transporter pulls drugs into liver cells before metabolism, so blocking it leaves statins in muscle, risking rhabdomyolysis.
Regulators’ single-timepoint tests underrate this risk, the unedited study found, since potency shifts with exposure time.
Sources: Nature