Tau Drives Mitochondrial Failure

LondonElectrons in mitochondria can flow backward, a new study finds.

It turns a decades-old correlation between tau tangles and energy failure into a causal pathway.

Tau protein pushes electron transport into reverse, and reversal floods cells with damaging reactive oxygen species.

The work comes from cell and animal models, with no human-tissue confirmation or drug target yet.

Sources: Nature