HoustonObesity blunted CAR-T cell attacks on breast tumors.
Most cell-therapy trials don’t screen patients by body weight, the group most likely to receive it.
In obese mice, engineered T cells lost glycolytic capacity and nearly failed to form the tissue-resident memory cells needed for lasting control.
The findings come from mouse models, and whether the same effect occurs in human patients remains untested.
How each outlet framed it
- Nature
- demonstrates obesity-associated inflammation upregulates tumor target B7-H3 while impairing CAR-T cell metabolic capacity
Sources: Nature