New York85.7% of injected volunteers made antibodies against H7 flu.

Side effects were mostly mild, but phase 1 measures safety and antibody response, not protection.

BPL-1357 contains 4 inactivated low-pathogenicity avian flu viruses, given by injection or nasal spray to 45 volunteers, 28 days apart.

Nasal doses produced only subtle responses, and injections produced no mucosal antibody response.

The authors say other dose levels and efficacy against infection still need testing.

How each outlet framed it
Nature Communications
reports that IM BPL-1357 raised serum IgG against H3, H5 and H7 over placebo, with adverse effects mostly mild, and mild injection-site pain more common in the IM arm

Sources: Nature Communications