BritainTwo gut bacteria together suppressed Clostridioides difficile across strains.
Patient data showed the Bacteroides-to-Escherichia ratio predicted resistance better than standard diversity metrics.
Fructan-derived sugars, vitamin B3 synthesis and competition for Stickland metabolism precursors drive the suppression, experiments showed.
The study did not test a Bacteroides-Escherichia therapy in patients.
Sources: Nature Communications