Prostaglandin Shields Breast Tumours

ChinaIn 360 patients, high prostaglandin signalling was linked to poor prognosis.

Triple-negative breast cancer is the most intractable subtype, with few therapeutic targets.

Prostaglandin activates PTGER1, which switches on KLK5 through the transcription factor JUN, and KLK5 suppresses MHC-I, hiding tumour antigens.

In preclinical models, blocking KLK5 improved immunotherapy efficacy, but the study reports no patient trial.

Sources: Nature