LondonAlphaGenome 2 finds 30% of causal immune-cell variants, not 16%.
The model reproduced a Nature finding that an ETS2 variant inflames the gut mainly through macrophages.
DeepMind trained it on 107 million single cells from 68 tissues, feeding the target cell’s state in at every stage.
Non-commercial researchers can use it through the AlphaGenome API now, and commercial users may apply for a private preview.
How each outlet framed it
- Zhidx
- reads the single-cell angle through disease genetics: one base change may hurt only specific cell types, and the model now predicts DNA methylation
Sources: Zhidx