BeijingAlphaFold cut CRISPR’s off-target editing rate to 5%.
Guide RNA runs just 18 bases in a 3-billion-base genome; Cas9 still binds near-matches and edits the wrong site.
The redesigned Cas9 also worked with the Cas12 protein, the researchers reported; combining it with prior variants remains untested.
Sources: Ars Technica